The Atacama Cosmology Telescope (ACT) has just begun observing the microwave sky at 140 through 280 GHz with over 3000 detectors. ACT exemplifies many of the technical challenges involved in measuring sky brightness with parts-per-million accuracy, along with the technical advances from sites like NASA-Goddard and NIST that propel the latest CMB experiments.
Nucleosome packing and unpacking are kinetic and mechanical in nature, involving translocation, rotation, force, and torque. Single molecule mechanical studies are ideally suited to probe these processes and have become powerful complementary tools to traditional biochemical and molecular biological approaches. They permit direct mechanical measurements of strengths and locations of histone-DNA interactions and how these interactions are governed by DNA sequences, histone covalent modifications and variants, and nucleosome remodeling. I will discuss our progress in mechanical studies of nucleosome stability and structure with specific focus on results obtained from optical trapping studies.
Contact:Eric D. Zimmerman